Advancements in research on the role of exosomes derived from immune cells in atherosclerosis
10.3969/j.issn.1000-4718.2025.00.002
- VernacularTitle:免疫细胞来源的外泌体在动脉粥样硬化中作用的研究进展
- Author:
Yiting ZHAO
1
;
Hewei QIN
Author Information
1. 河南中医药大学康复医学院,河南 郑州 450046
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
immune cells;
exosomes;
inflammation;
immune regulation
- From:
Chinese Journal of Pathophysiology
2025;41(2):382-387
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis(AS)is a chronic inflammatory disease involving various immune cells and is char-acterized by lipid deposition and inflammatory response.In recent years,the field of exosome research has been rapidly developed,thereby enhancing our comprehension of their role in AS.Immune cell-derived exosomes are extracellular vesi-cles secreted by immune cells that possess specificity,stability,and biocompatibility.These exosomes have the capacity to induce diverse responses including modulating gene transcription and regulating cytokine production,thereby influenc-ing the body's inflammatory and immune response.During AS progression,these exosomes primarily participate in patho-logical processes including endothelial dysfunction,lipid deposition,vascular calcification,and plaque rupture,all of which significantly influence the development of AS.This review is focused on exploring the role of exosomes derived from monocytes,macrophages,neutrophils,lymphocytes,as well as other immune cells(neutrophils,eosinophils,mast cells,and myeloid-derived suppressor cells)in AS,aiming to offer insights for diagnosis and clinical treatment.
