Research progress of Dickkopf family in colorectal cancer
10.3969/j.issn.1000-4718.2025.02.025
- VernacularTitle:分泌蛋白Dickkopf家族在结直肠癌中的研究进展
- Author:
Yun FANG
1
;
Yinghui WANG
;
Xiang ZHOU
Author Information
1. 贵阳市第二人民医院,贵州 贵阳 550000
- Publication Type:Journal Article
- Keywords:
Dickkopf proteins;
colorectal cancer;
Wnt/β-catenin signaling pathway
- From:
Chinese Journal of Pathophysiology
2025;41(2):412-416
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer(CRC)is currently the third most prevalent tumor and the second leading cause of cancer-related mortality.Abnormal Wnt/β-catenin signaling pathway is one of the key signaling pathways leading to the occurrence and development of CRC.The Dickkopf family,consisting of secreted proteins,acts as antagonists to this sig-naling pathway and significantly influences the progression of CRC.The family includes Dickkopf-1 to Dickkopf-4 secret-ed proteins,with each member exhibiting distinct roles in the context of CRC.This article aimed to provide a comprehen-sive overview of the research advancements concerning the secreted Dickkopf family's role in CRC.
