Preventive effect of 1,8-cineole on caries induced by Streptococcus mutans in rats
10.3969/j.issn.1001-3733.2025.06.006
- VernacularTitle:1,8-桉叶油素对变异链球菌诱导的大鼠龋病的预防效果研究
- Author:
Xiaoxi JIANG
1
;
Xinyi YANG
;
Li HE
;
Shiting LI
;
Chunhui LI
Author Information
1. 646000 泸州,西南医科大学附属口腔医院牙周黏膜病科
- Publication Type:Journal Article
- Keywords:
1,8-cineole;
Streptococcus mutans;
Animal model;
Dental caries;
Prevention
- From:
Journal of Practical Stomatology
2025;41(6):763-767
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the possibility of 1,8-cineole in the prevention of Streptococcus mutans(S.mutans)induced dental caries in rats.Methods:40 specific pathogen-free rats were randomly divided into 5 groups(n=8):distilled water group(negative control group),chlorhexidine group(positive control group),and eucalyptin low(MIC),medium(2MIC)and high(4MIC)dose groups.The plates were streaked with saliva samples,and calculated the number of S.mutans colonies and the ratio of the total number of colonies.Keyes' method was used to evaluate the caries damage of the jaws specimens.Results:At the end of the experiment,the proportion(％)of S.mutans in the oral cavity of the drug groups decreased(P＜0.000 1),but there was no significant difference between the drug group and the positive control group(P＜0.05).At the end of the experiment,compared with the negative control group,the scores of each grade in the drug group decreased(P＜0.05),but there was no significant differ-ence between positive control group and each 1,8-cineole group(P＞0.05),and among the 3 1,8-cineole dose groups(P＞0.05).Conclusion:1,8-cineole at the MIC can inhibit the growth of S.mutans in the oral cavity of rats with dental caries and reduce the frequency and severity of dental caries.
