A randomized controlled study of deproteinized calf blood extract in the treatment of diabetic cataract with dry eye after phacoemulsification
10.3760/cma.j.cn115989-20240111-00016
- VernacularTitle:小牛血去蛋白提取物治疗糖尿病性白内障合并干眼患者超声乳化术后干眼的随机对照研究
- Author:
Fengjie LI
1
;
Can ZHAO
1
;
Li PEI
1
;
Jijun SUN
1
;
Xiaofeng LI
1
;
Mengdi NIU
1
;
Yabin TIAN
1
;
Xiaozhen HE
1
;
Jincong WANG
1
;
Ting WANG
1
Author Information
1. 山东第一医科大学附属眼科研究所 山东第一医科大学附属眼科医院（山东省眼科医院） 山东省眼科学重点实验室-省部共建国家重点实验室培训基地 山东第一医科大学眼科学院，济南 250021
- Publication Type:Journal Article
- Keywords:
Dry eye;
Diabetes;
Cataract;
Deproteinized calf blood extract eye drops;
Sodium hyaluronate eye drops;
Phacoemulsification
- From:
Chinese Journal of Experimental Ophthalmology
2025;43(4):343-349
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the clinical effect of deproteinized calf blood extract (DCBE) eye drops and 0.3% sodium hyaluronate eye drops in the treatment of diabetic cataract patients with dry eye after phacoemulsification.Methods:A randomized controlled study was performed.A total of 112 patients (116 eyes) with type Ⅱ diabetes combined with cataract and dry eye who underwent phacoemulsification in the Eye Hospital of Shandong First Medical University from January 2022 to September 2022 were selected.Patients were divided into DCBE group (49 cases, 51 eyes) and sodium hyaluronate group (63 cases, 65 eyes) by the random number table method.Patients received DCBE eye drops and 0.3% sodium hyaluronate eye drops after surgery according to grouping.Preoperative and postoperative 1 week, 1 month subjective symptoms of dry eye, corneal edema grade, tear film breakup time (TBUT), corneal fluorescein staining (CFS) and Schirmer Ⅰ test (SⅠt) results were recorded and compared.This study adhered to the Declaration of Helsinki.The study protocol was approved by the Ethics Committee of Eye Hospital of Shandong First Medical University (No.SDSYKYY202112-1).Written informed consent was obtained from each subject.Results:There were significant differences in dry eye symptom score, TBUT and SⅠt at different time points between before and after surgery ( Ftime=323.202, 102.771, 151.876; all P<0.001).Dry eye symptom score decreased and SⅠt increased in the two groups at 1 week and 1 month after surgery compared with before surgery, and the differences were statistically significant (all P<0.017).TBUT was longer at 1 week and 1 month after surgery compared with before surgery in the DCBE group, and TBUT at 1 month after surgery was longer than that before surgery in the sodium hyaluronate group, and the differences were statistically significant (all P<0.017).There were statistically significant differences in CFS scores between the two groups at different time points before and after surgery ( Fgroup=5.391, P=0.022; Ftime=142.402, P<0.001).The CFS scores of both groups at 1 week and 1 month after surgery were lower than those before surgery, and CFS scores in the DCBE group were lower than those in the sodium hyaluronate group, with statistically significant differences (all P<0.017).One week after surgery, the proportion of patients with corneal edema in the DCBE group was 5.9%(3/51), which was significantly lower than 20.0%(13/65) in the sodium hyaluronate group ( χ2=4.790, P=0.029). Conclusions:DCBE eye drops can promote corneal repair, stabilize tear film and improve dry eye discomfort in early postoperative period in diabetic cataract, and its overall effect is better than 0.3% sodium hyaluronate eye drops.
