Research progress on the production and application of cellular models of diabetic retinopathy
10.3760/cma.j.cn115989-20211010-00557
- VernacularTitle:糖尿病视网膜病变细胞模型的制作及应用研究进展
- Author:
Ruiyan FAN
1
;
Xiaorong LI
1
Author Information
1. 天津医科大学眼科医院 天津医科大学眼视光学院 天津医科大学眼科研究所 国家眼耳鼻喉疾病临床医学研究中心天津市分中心 天津市视网膜功能与疾病重点实验室，天津 300384
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy;
Pathogenesis;
Cell model;
Retinal neurovascular unit
- From:
Chinese Journal of Experimental Ophthalmology
2025;43(10):960-965
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy (DR) is one of the most common serious microvascular complications of diabetes.Many studies have shown that DR is caused by damage to the retinal neurovascular unit.As our understanding of the pathogenesis of DR is still limited, existing treatment methods have not achieved the ideal effect of delaying progression and curing the disease at the fundamental level of pathogenesis.To further clarify the occurrence and development mechanism of DR and explore more effective prevention and treatment methods, researchers have developed and used various cell models targeting specific cells and signaling pathways.Most of these cell models can simulate part of the pathological changes of DR, but they cannot fully simulate the physiological and pathological environments in the body.Therefore, researchers must consider the research purpose and observation indicators comprehensively, select an appropriate cell model, and confirm it through animal experiments.This review provides a comprehensive discussion about the normal distribution, physiological functions, pathological changes of DR and the modeling methods, pathological manifestations and research applications of these models.
