Research progress on the role of IFN-β in viral infection

VernacularTitle:IFN-β在病毒感染中的作用研究进展
Author: Shuai SHAO ¹ ; Xiaolan JI ; Yiyang FAN ; Jialin BAI ; Qiongyi LI
Author Information

1. 730030 兰州,西北民族大学生命科学与工程学院;730030 兰州,西北民族大学生物医学研究中心生物工程与技术国家民委重点实验室;730030 兰州,西北民族大学细胞基质疫苗关键技术与产业化教育部工程研究中心;730030 兰州,甘肃省动物细胞技术创新中心
Publication Type:Journal Article
Keywords: Interferon; IFN-β; Antiviral; Infection
From: Immunological Journal 2024;40(11):844-855
CountryChina
Language:Chinese
Abstract: IFN-β,secreted by fibroblasts,leukocytes,epithelial cells and other cells,plays an important role in the intrinsic immune response,and involves in the body's anti-viral immune response by inducing a variety of antiviral genes.It has various biological functions such as inhibiting viral replication,anti-parasite,influencing cell proliferation,participating in immune regulation,and anti-tumor.This paper mainly reviews the activation of IFN-β and its antiviral effects after DNA virus and RNA virus infections and the immune escape mechanism evolved by some viruses,and summarizes the progress of the research on the interferon signaling pathway regulated by viral infections,so as to provide references for the future research on the mechanism of antiviral infections and their prevention and treatment.