Research progress on mouse models of uveal melanoma
10.3760/cma.j.cn115989-20240604-00146
- VernacularTitle:葡萄膜黑色素瘤小鼠模型的研究进展
- Author:
Xiaoyu GUO
1
;
Yiqiao XING
1
;
Changzheng CHEN
1
Author Information
1. 武汉大学人民医院眼科，武汉 430060
- Publication Type:Journal Article
- Keywords:
Uveal melanoma;
Mouse models;
Allograft models;
Xenograft models;
Genetic engineering model
- From:
Chinese Journal of Experimental Ophthalmology
2025;43(9):871-875
- CountryChina
- Language:Chinese
-
Abstract:
Uveal melanoma is the most prominent aggressive intraocular cancer, which threatens the survival and vision of patients.Although the primary tumor can be controlled in various ways, nearly half of patients eventually die from liver metastases.Therefore, it is necessary to explore effective treatment therapies to improve the quality and survival time of patients.Mice model is the most common animal model for uveal melanoma.Several mouse models are available to be selected for different research purposes.Current mouse models of uveal melanoma include allograft models, xenograft models and genetic engineering models.Although the mouse model has been used in the study of uveal melanoma for more than 40 years, there is little literature on the subject at home and abroad due to the diversity of animal models and the complexity of genomic variation in uveal melanoma.This article reviews relevant domestic and international studies on mouse models of uveal melanoma to focus on the advantages, limitations and application range of existing models, providing references for animal studies of uveal melanoma.
