Research progress in the involvement of angiocrine in choroidal neovascularization
10.3760/cma.j.cn115989-20211016-00564
- VernacularTitle:血管旁分泌参与脉络膜新生血管生成的研究进展
- Author:
Yali NIU
1
;
Yutong JING
1
;
Tianfang CHANG
1
;
Guorui DOU
1
Author Information
1. 空军军医大学第一附属医院眼科 全军眼科研究所，西安 710032
- Publication Type:Journal Article
- Keywords:
Choroidal neovascularization;
Angiocrine;
Endothelial cells
- From:
Chinese Journal of Experimental Ophthalmology
2025;43(9):866-870
- CountryChina
- Language:Chinese
-
Abstract:
Choroidal neovascularization (CNV) is a common fundus neovascularization disease, which often leads to irreversible vision loss.The pathological mechanisms are extremely complex, involving the participation of a variety of cells and cellular contacts.Currently, there are still many deficiencies in the treatment of CNV.We are concerned that blood vessels are not only a " conduits" for transporting nutrients and metabolic waste, but also providing angiocrine factors for organ growth and development.A variety of tissue-specific vascular endothelial cells have been proved to be able to deliver a variety of cytokines under certain conditions, which act on surrounding cells and participate in the control of angiogenesis and homeostasis.Therefore, this review focuses on the research progress on the involvement of angiocrine in pericytes, retinal pigment epithelial cells, mononuclear macrophages, neutrophils and endothelial precursor cells in CNV through various forms such as extracellular vesicles, in order to provide new ideas for the treatment of CNV.
