Regulating effect of non-coding RNAs in thyroid-associated ophthalmopathy
10.3760/cma.j.cn115989-20210309-00155
- VernacularTitle:非编码RNA在甲状腺相关眼病中的调控作用
- Author:
Zifan YUE
1
;
Ruili WEI
Author Information
1. 海军军医大学第二附属医院上海长征医院眼科，上海 200003
- Publication Type:Journal Article
- Keywords:
Thyroid-associated ophthalmopathy;
Non-coding RNA;
MicroRNA;
Regulating effect
- From:
Chinese Journal of Experimental Ophthalmology
2025;43(7):675-680
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid-associated ophthalmopathy (TAO) is related to environmental, genetic and immune factors, mainly involving the autoimmune response of the thyroid and extraocular muscles.However, its specific pathogenesis is unclear.Non-coding RNAs (ncRNAs), the transcription products of RNA, are mainly divided into long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and microRNAs (miRNAs).ncRNAs regulate molecular functions and biological processes in cells and the body at the transcription and pre-transcription levels.Recent studies have found that ncRNAs, especially miRNAs, play an important biological regulatory role in the pathogenesis of TAO.This article explains how miRNAs, such as miRNA-146a, miRNA-155, miRNA-21, etc., lncRNAs and circRNAs are involved in the pathogenesis of TAO, such as inflammation mediation, adipogenesis and fibrosis, and cell proliferation, in order to provide new ideas for future research on the pathogenesis of TAO and clarify the important inspiration and guiding significance of ncRNAs for the targeted intervention and early treatment of TAO.
