Research on simple limbal epithelial transplantation and its application prospects
10.3760/cma.j.cn115989-20210115-00042
- VernacularTitle:角膜缘干细胞种植术研究进展及应用前景
- Author:
Yinghui WANG
1
;
Ying JIE
1
Author Information
1. 首都医科大学附属北京同仁医院 北京同仁眼科中心 北京市眼科研究所 北京市眼科学与视觉科学重点实验室，北京 100730
- Publication Type:Journal Article
- Keywords:
Limbal stem cells;
Limbal stem cell deficiency;
Simple limbal epithelial transplantation
- From:
Chinese Journal of Experimental Ophthalmology
2025;43(4):364-367
- CountryChina
- Language:Chinese
-
Abstract:
Damage to limbal due to injury or disease can lead to limbal stem cell deficiency (LSCD).Severe LSCD is difficult to diagnose and treat clinically, while limbal stem cell transplantation (LSCT) is the main treatment.Simple limbal epithelial transplantation (SLET) is a novel technique for LSCT.The procedure involves removing the fibrovascular pannus from the recipient eye, cutting the limbal tissue from the donor eye into tiny pieces, transplanting the epithelial side up onto the corneal surface of the recipient eye, and using amniotic membrane as a carrier to repair the ocular surface.Regular follow-up shows that the corneal epithelialization is completed at approximately two weeks postoperatively through the continuous expansion and migration of the tissue.Compared with other LSCT procedures, SLET is simple to perform, requires less biopsy, and has good repeatability.In addition, SLET has shown good clinical prospects.This article reviews the research progress of SLET.
