Research progress on the role of Cx36 in retinal signal transduction and myopia progression
10.3760/cma.j.cn115989-20220921-00440
- VernacularTitle:Cx36在视网膜信号传导及近视进展中的作用研究进展
- Author:
Hao ZHANG
1
;
Junguo GUO
;
Hongsheng BI
Author Information
1. 山东中医药大学附属眼科医院，济南 250002
- Publication Type:Journal Article
- Keywords:
Retina;
Connexin 36;
Myopia;
Signal transduction
- From:
Chinese Journal of Experimental Ophthalmology
2025;43(2):169-173
- CountryChina
- Language:Chinese
-
Abstract:
The retina is a crucial site for mediating the conversion of external light signals into neural electrical signals.Connexin (Cx), as the basic structural and functional protein molecule of gap junction channels, plays an important role in maintaining the functional homeostasis of the retina.Cx36 has physiological functions in aspects such as retinal information transmission and biochemical factor regulation, and is involved in the formation of myopia.The " local retina-sclera remodeling" theory holds that abnormal visual information acts on the retina, causing sclera remodeling through retinal pigment epithelium-choroid signal transduction, and ultimately leading to myopia.Exploring the role and mechanism of retinal Cx36 in visual development and myopia formation is of great guiding significance for myopia prevention and control.This article reviews the research progress in the physiological functions of Cx36 in the retina and its role in myopia development in recent years.
