Progress in research on the mechanism of E-cadherin in age-related macular degeneration
10.13389/j.cnki.rao.2025.0169
- VernacularTitle:E-钙黏蛋白在年龄相关性黄斑变性中的作用机制研究进展
- Author:
Mengqi GAO
1
;
Ning YANG
1
;
Siqi FENG
1
;
Xinrong XU
1
Author Information
1. 210029 江苏省南京市,南京中医药大学附属医院
- Publication Type:Journal Article
- Keywords:
E-cadherin;
age-related macular degeneration;
inflammation;
oxidative stress;
neovascularization
- From:
Recent Advances in Ophthalmology
2025;45(12):986-990
- CountryChina
- Language:Chinese
-
Abstract:
The key pathological feature of age-related macular degeneration(AMD)is dysfunction of retinal pigment epithelial cells.Cell adhesion,serving as the biological basis for dynamic interactions between cells and between cells and the extracellular matrix,regulates tissue homeostasis through transmembrane signaling networks mediated by adhesion molecules.Studies have shown that the aberrant expression of E-cadherin,which offers advantages such as dynamic plas-ticity,tissue specificity,and signal transduction capability,is closely associated with the pathological mechanism of AMD.Targeting E-cadherin-related molecules may thus serve as a potential strategy for AMD intervention.This article reviews re-cent advances in the molecular regulatory mechanisms and therapeutic research concerning E-cadherin in AMD,aiming to provide a theoretical basis for its clinical translation.
