Role of inflammation in the development of high myopia: current research insights
10.3760/cma.j.cn115989-20231017-00135
- VernacularTitle:炎症在高度近视发病中的作用研究进展
- Author:
Zhuang HAO
1
;
Jian ZHOU
1
Author Information
1. 空军军医大学西京医院眼科 全军眼科研究所，西安 710032
- Publication Type:Journal Article
- Keywords:
High myopia;
Pathological myopia;
Inflammation;
Interleukin;
Transforming growth factor-β;
Matrix metalloproteinase;
Monocyte chemotactic factor-1
- From:
Chinese Journal of Experimental Ophthalmology
2025;43(2):174-180
- CountryChina
- Language:Chinese
-
Abstract:
High myopia (HM) is a leading cause of low vision and blindness worldwide and is becoming a visual health concern globally.The complicated pathogenesis of HM remains an intense focus.Recently, the role of inflammation in HM has been gaining increasing attention.Based on the changes in the levels of local intraocular inflammatory cytokines and markers of systemic inflammation, this article reviews the relationship between inflammation and HM from local inflammatory cytokines in the eye and systemic inflammation, discusses the potential mechanisms of interleukin, transforming growth factor-β, matrix metalloproteinase-2, monocyte chemotactic protein-1, etc.in the pathogenesis of HM, which means that inflammation participates in the occurrence and development of HM by causing retinal cell apoptosis, scleral tissue remodeling, and lens volume changes.Moreover, inflammatory cytokines in the peripheral blood of HM patients are significantly elevated.Inflammatory parameters, such as the neutrophil-to-lymphocyte ratio, are positively correlated with axial length, suggesting that systemic inflammation may also influence the pathological process of HM.Further investigation into the role of inflammation in HM may provide new insights into identifying predictive biomarkers and therapeutic targets for HM.
