Associations and Sex Differences Between Chinese Visceral Adiposity Index and Risk of Cardiovascular Disease
10.3969/j.issn.1000-3614.2025.02.007
- VernacularTitle:中国人内脏脂肪指数与心血管疾病发病风险的关联及性别差异
- Author:
Tao ZHOU
1
;
Chenyang LI
;
Chenxi YUAN
;
Chong SHEN
;
Shufeng CHEN
;
Jianxin LI
;
Jie CAO
;
Keyong HUANG
;
Dongsheng HU
;
Jianfeng HUANG
;
Xiangfeng LU
;
Dongfeng GU
;
Fangchao LIU
Author Information
1. 南京医科大学 公共卫生学院 流行病学系,南京 211166
- Publication Type:Journal Article
- Keywords:
Chinese visceral adiposity index;
cardiovascular disease;
cohort study;
sex difference
- From:
Chinese Circulation Journal
2025;40(2):157-163
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:This study aims to investigate the association between Chinese visceral adiposity index(CVAI)and the risk of cardiovascular disease(CVD),and explore the sex differences.Methods:Participants were screened from the three sub-cohorts of Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR)project,baseline information on body measure and biochemistry examinations were collected from 1998,2000-2001,and 2007-2008,separately.Participants were followed up to 2015.Cohort-stratified Cox proportional risk models were used to analyze the relationship between CVAI,both in continuous(per standard deviation increase)and categorical(quartiles,with Q1 as reference)scales,and CVD risk in the total population,men and women.The multiplicative interaction between sex and CVAI on CVD risk were calculated.Restricted cubic spline regression was employed to investigate the dose-response relationship.Results:A total of 98 464 participants without CVD at baseline were included.During the 723 508 person-years of follow-up,3 605 CVD events were recorded.After multivariate adjustment,the HRs(95％CIs)of CVD were 1.25(1.20-1.29),1.09(1.04-1.15),and 1.54(1.46-1.64)for per standard deviation increment in CVAI in the general population,men and women,respectively.Besides,compared with Q1 group,the HRs(95％CIs)in Q4 group were 1.87(1.67-2.10),1.33(1.14-1.54)and 3.84(3.09-4.78),correspondingly,and the effect of CVAI on the risk of CVD was significantly higher in women than in men(Pinteraction<0.05).Additionally,there was a positive dose-response relationship between CVAI and the risk of CVD.Conclusions:Elevated CVAI is an independent risk factor for CVD,especially in women.
