Analysis of Related Factors of Poor Collateral Circulation Formation in Patients With Chronic Total Occlusion Lesion of Coronary Arteries
10.3969/j.issn.1000-3614.2025.02.005
- VernacularTitle:冠状动脉慢性完全闭塞病变侧支循环形成不良的相关因素分析
- Author:
Yihua WANG
1
;
Jin ZHANG
;
Yujiao JIANG
;
Bingxin MEN
;
Nana HU
;
Yaping ZHANG
Author Information
1. 兰州大学第一临床医学院,兰州 730000;兰州大学第一医院 心内科 甘肃省心血管疾病重点实验室,兰州 730013
- Publication Type:Journal Article
- Keywords:
coronary artery;
chronic total occlusion lesion;
collateral circulation;
risk factors;
inflammatory index
- From:
Chinese Circulation Journal
2025;40(2):145-150
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To investigate the factors affecting the formation of coronary collateral circulation(CCC)in patients with chronic total occlusion(CTO)lesion of coronary artery.Methods:A total of 305 consecutive patients who were hospitalized in the department of cardiology of the First Hospital of Lanzhou University from December 2022 to December 2023 and CTO lesions were confirmed by coronary angiography in at least one major coronary artery were included.The clinical data were collected,and the patients were divided into poor CCC group(Rentrop grade 0-1,n=109)and good CCC group(Rentrop grade 2-3,n=196)according to Rentrop criteria.Univariate logistic regression and multivariate logistic regression analysis were used to investigate the risk factors of poor CCC formation in CTO lesion patients.Results:There were 109 patients with poor CCC formation and 196 patients with good CCC formation in this cohort.The levels of white blood cell count,neutrophil count,platelet count,platelet to lymphocyte ratio,neutrophil to lymphocyte ratio,systemic immunoinflammatory index(SII),lipoprotein a and fibringen(Fib)were significantly higher,lymphocyte count and mean platelet volume were significantly lower in patients with poor CCC formation than in patients with good CCC formation(all P<0.05).Multivariate logistic regression analysis showed that higher SII(OR=1.004,95%CI:1.003-1.006,P<0.001),Fib(OR=1.546,95%CI:1.038-2.301,P=0.032)levels were independent predictors of poor CCC formation in CTO lesion patients.Conclusions:Higher levels of SII and Fib are independently correlated with poor CCC formation,which may be used as clinical predictor of poor CCC formation in CTO lesion patients.
