Study on the protective mechanisms of leptin and ghrelin with retinal ganglion cells in glaucoma
10.3760/cma.j.cn115989-20220414-00162
- VernacularTitle:瘦素和胃饥饿素与青光眼视网膜神经节细胞的保护机制研究
- Author:
Keyu HU
1
;
Hanruo LIU
1
Author Information
1. 首都医科大学附属北京同仁医院 北京同仁眼科中心 北京市眼科研究所 眼科学与视觉科学北京市重点实验室，北京 100730
- Publication Type:Journal Article
- Keywords:
Glaucoma;
Leptin;
Ghrelin;
Retinal ganglion cells;
Obesity
- From:
Chinese Journal of Experimental Ophthalmology
2025;43(5):459-465
- CountryChina
- Language:Chinese
-
Abstract:
Glaucoma, a group of diseases characterized by progressive optic nerve degeneration, is the world's first irreversible blinding eye disease.There is increasing evidence that the pathogenesis of glaucomatous neurodegeneration and neurodegenerative diseases of the central nervous system share many similarities.Epidemiologic studies have shown that there is a close relationship between obesity, metabolic dysfunction and neurodegeneration.Changes in serum levels of leptin and ghrelin, two major metabolic factors, are important links in the pathogenesis of glaucomatous retinal ganglion cells.Leptin resistance and ghrelin resistance in physiological states support that obesity is an independent risk factor for the pathogenesis of glaucoma.This review explores the protective effects of leptin and ghrelin on retinal ganglion cells and the optic nerve and considers their potential role in the prevention and treatment of glaucoma.
