The Effect of Platelet Irradiation on the Efficacy and Safety of Platelet Transfusion in Children with Hematological Disorders
10.19746/j.cnki.issn1009-2137.2025.06.034
- VernacularTitle:血小板辐照对血液病患儿血小板输注有效性和安全性的影响
- Author:
Xin CHEN
1
;
Qin LIU
1
;
Hao LI
1
;
Jia WANG
1
;
Hong-Bing HU
1
Author Information
1. 华中科技大学同济医学院附属武汉儿童医院(武汉市妇幼保健院)输血科,湖北武汉 430015
- Publication Type:Journal Article
- Keywords:
platelet transfusion;
irradiation;
hematological disorders;
children
- From:
Journal of Experimental Hematology
2025;33(6):1774-1778
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of platelet irradiation on the efficacy and safety of platelet transfusion in children with hematological disorders.Methods:The platelet transfusion of 56 pediatric patients in the Hematology Department of Wuhan Children's Hospital from January to December 2023 were retrospective analyzed.According to whether the platelets transfused by the patient have been irradiated,they are divided into irradiation group and non irradiation group.The effect of platelet irradiation on efficacy rate of transfusion and incidence of transfusion adverse reactions was analyzed.Results:Fifty-six patients with hematological disorders received 608 platelet transfusions,with 83 transfusions ineffective and an inefficiency rate of 13.65％.Twenty-nine times of adverse transfusion reactions occurred,with a transfusion reaction incidence rate of 4.77％.The 24-hour CCI value of the irradiation group was lower than that of the non irradiation group(Z=4.120,P＜0.01),and the effective rate of transfusion in the irradiation group was lower than that in the non irradiation group(x2=8.595,P＜0.01).The incidence of adverse reactions during transfusion in the irradiation group was lower than that in the non irradiation group(x2=4.153,P＜0.05).In children with acute leukemia,there were statistical differences in 24 h CCI,the effective rate of transfusion,and adverse transfusion reactions between the irradiation and non-irradiation groups.Conclusion:Platelet irradiation can reduce the effective rate of platelet transfusion in children with hematological disorders,but can reduce the incidence of adverse transfusion reactions.To ensure the safety of blood use for pediatric patients,it is recommended to transfuse irradiated platelets to individuals who are susceptible to transfusion associated graft-versus-host disease(TA-GVHD),especially children with acute leukemia.
