Research Progress on the Function of Calpain in Atherosclerosis
10.3969/j.issn.1000-3614.2025.02.015
- VernacularTitle:钙蛋白酶在动脉粥样硬化中的作用及研究进展
- Author:
Jiaqi ZHANG
1
;
Xiting WANG
1
;
Xiahuan CHEN
1
;
Meilin LIU
1
Author Information
1. 北京大学第一医院 老年病内科,北京 100034
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
calpain;
inflammation;
cardiovascular disease
- From:
Chinese Circulation Journal
2025;40(2):203-208
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis is a severe disease threatening human health,leading to tremendous consequences such as acute coronary syndrome,myocardial infarction,and stroke.The onset and progression of atherosclerosis are attributed to a chronic inflammatory process,closely associated with the biological activities of various cells.Calpain,a Ca2+-dependent cysteine protease within cells,plays a pivotal role in this context by regulating a plethora of substrates through restricted catalysis of protein hydrolysis,thereby participating in pathological and physiological processes including endothelial damage,inflammatory response,and lipid metabolism.This review summarizes the role of calpain in the development of atherosclerosis and the latest research progress in the application of calpain inhibitors for treatment of atherosclerosis,offering new insights for the clinical realization of personalized and precise treatment of atherosclerosis.
