Research progress on the regulatory effect of lncRNA MALAT1 on neovascularization in ischemic retinopathy
10.3760/cma.j.cn115989-20211130-00661
- VernacularTitle:长链非编码RNA MALAT1对缺血性视网膜病变新生血管形成的调控作用研究进展
- Author:
Zhaojin LI
1
;
Yu DI
1
Author Information
1. 中国医科大学附属盛京医院眼科，沈阳 110000
- Publication Type:Journal Article
- Keywords:
Long non-coding RNA;
Epigenetics;
Oxidative stress;
Metastasis-associated lung adenocarcinoma transcript 1;
Ischemic retinopathies
- From:
Chinese Journal of Experimental Ophthalmology
2025;43(1):92-96
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic retinopathies (IRs) with neovascularization often severely impair vision and even lead to blindness.Studies have shown that long non-coding RNA (lncRNA) MALAT1 is co-expressed with protein-coding genes that regulate retinal cell development.Recent studies have also confirmed that MALAT1 is up-regulated in IRs and has the effects of inducing oxidative stress and inflammatory responses, promoting vascular endothelial cell proliferation, migration and angiogenesis, and changing epigenetic modifications, which plays an important role in the pathogenesis and regulation of retinal neovascularization.This article summarizes the current research status of MALAT1 in IRs from the aspects of the pathogenesis of IRs, the expression and function of MALAT1 in the retina and its role in angiogenesis, oxidative stress, inflammation, vascular endothelial damage, epigenetic regulation, cell cycle, etc., and explores its role in the occurrence and development of retinal neovascularization to provide a deeper understanding of the mechanism of MALAT1 in the neovascularization of IRs to help develop its targeted treatment strategies.
