Breaking the dilemma of polymyxin resistance:forefront exploration of antimicrobial sensitizers
10.12138/j.issn.1671-9638.20252288
- VernacularTitle:多黏菌素耐药困境破局:抗菌药物增敏剂的前沿探索
- Author:
Xin CHEN
1
;
Ci SONG
;
Yanxi WANG
;
Jiaqi ZHANG
;
Yanan WANG
;
Zhiliang SUN
;
Jiyun LI
Author Information
1. 湖南农业大学动物医学院,湖南长沙 410125
- Publication Type:Journal Article
- Keywords:
polymyxin;
mcr-1;
sensitizer;
bacterial resistance
- From:
Chinese Journal of Infection Control
2025;24(11):1681-1690
- CountryChina
- Language:Chinese
-
Abstract:
Polymyxin serves as the"last line of defense"for treating infection with multidrug-resistant Gram-ne-gative bacteria.However,the emergence and spread of polymyxin-resistant genes such as mcr-1 severely weakens its clinical efficacy.This paper systematically summarizes the antimicrobial and resistance mechanisms of polymy-xin,comprehensively summarizes the current research progresses in polymyxin sensitizers particular focusing on three aspects:natural compounds,synthetic small molecules,and drug repurposing.Furthermore,this paper explores the innovative strategies of gene intervention,new targets,and nanotechnology-based formulations in the develop-ment of sensitizer,aiming to provide systematic theoretical support and research ideas against polymyxin resistance.
