Therapeutic effect of felodipine sustained-release tablets combined with trimetazidine in the treatment of elderly patients with HHD
10.3969/j.issn.1008-0074.2025.01.17
- VernacularTitle:非洛地平缓释片联合曲美他嗪治疗老年HHD患者的疗效
- Author:
Xiao-hui ZHENG
1
;
Hong-qiang LIU
1
Author Information
1. 上海健康医学院附属崇明医院心内科,上海 202155
- Publication Type:Journal Article
- Keywords:
Hypertension;
Heart diseases;
Felodipine;
Trimetazidine
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2025;34(1):81-85
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of felodipine sustained-release tablets combined with trimetazidine on cardiac function,inflammatory factors and blood pressure in elderly patients with hypertensive heart disease(HHD).Methods:This randomized controlled study enrolled 130 HHD patients admitted in Chongming Hospital Affiliated to Shanghai University of Medicine&Health Sciences between January 2020 and December 2020.They were divided into trimetazidine group(n=65,trimetazidine therapy)and combined treatment group(n=65,addi-tional felodipine treatment).Both groups were treated for continuous 8 weeks.Therapeutic effect,cardiac func-tion,inflammatory factor levels,blood pressure and incidence of adverse reactions were compared between two groups.Results:After 8-week treatment,compared with patients in trimetazidine group,those in combined treat-ment group had significant higher total effective rate(93.85％vs.76.92％),left ventricular ejection fraction(LVEF)[(51.31±8.42)％vs.(43.21±8.25)％],cardiac index(CI)[(2.78±0.53)L·min-1·m-2 vs.(2.39±0.49)L·min-1·m-2],left ventricular early-diastolic peak flow velocity/early-late peak flow velocity(E/A)[(1.19±0.42)vs.(0.91±0.25)],and significant lower systolic blood pressure(SBP)[(118.11±11.41)mmHg vs.(137.21±13.52)mmHg],diastolic blood pressure(DBP)[(66.21±7.22)mmHg vs.(76.01±8.35)mmHg](P＜0.01 all).We detected no significant difference in incidence of adverse reactions between two groups(P=1.000).Conclusion:The combination of felodipine and trimetazidine in HHD patients could improve cardiac function,blood pressure without increasing risk of adverse reactions.
