The biological role of YTHDF2 and its application in tumors
10.3969/j.issn.1006-5725.2025.04.023
- VernacularTitle:YTH结构域N6-甲基腺嘌呤RNA结合蛋白2的生物学作用及其在肿瘤中应用的研究进展
- Author:
Dengxinjie SHI
1
;
Hongjin SHI
;
Nan ZHANG
;
Shi FU
;
Qun WANG
;
Haonan DONG
;
Jiansong WANG
;
Haidan LI
;
Haifeng WANG
Author Information
1. 昆明医科大学第二附属医院泌尿外科(云南 昆明 650000)
- Publication Type:Journal Article
- Keywords:
YTHDF2;
m6A modification;
biological role;
tumor;
diagnostic marker;
therapeu-tic target;
prognostic evaluation
- From:
The Journal of Practical Medicine
2025;41(4):615-620
- CountryChina
- Language:Chinese
-
Abstract:
YTHDF2 is a key m6A RNA modification"reader"that plays a crucial role in cell biological processes and tumor development.This review deeply explores the biological role of YTHDF2 and the advances in its application in tumors.The YTHDF2 structures are divided into mRNA procsomes and YTH domains,which recognize and bind m6A modified RNA molecules.It plays a biological role by promoting mRNA degradation,regu-lating cell signaling pathways and metabolism,and can regulate macrophage function and maintain an immunosup-pressive state in the tumor microenvironment.YTHDF2 has the potential to serve as diagnostic markers,therapeu-tic targets and prognostic evaluation biomarkers in different tumors,but currently relevant studies are insufficient in sample size,molecular mechanism and clinical application.In the future,research can be conducted on compre-hensive clinical research,in-depth analysis of molecular mechanisms,and research and development of optimized treatment strategies.
