Efficacy of HP in series with CRRT integrated combined blood purification under extracorporeal citrate anticoagulation in the treatment of severe HTG-AP
10.3969/j.issn.1006-5725.2025.04.015
- VernacularTitle:枸橼酸体外抗凝下血液灌流串联连续肾脏替代治疗一体化组合式血液净化治疗重症高甘油三酯血症性急性胰腺炎的疗效
- Author:
Le WU
1
;
Runlu GENG
;
Jingjiang ZHOU
;
Li LI
;
Lei XU
;
Jie KANG
;
Bin LU
;
Ying YE
;
Hongning YANG
;
Weichao DING
Author Information
1. 徐州医科大学附属医院急诊医学科(江苏 徐州 221002);徐州医科大学研究生院(江苏 徐州 221002);江苏省卫生应急研究所(江苏 徐州 221002)
- Publication Type:Journal Article
- Keywords:
hemoperfusion;
continuous renal replacement therapy;
extracorporeal citrate anticoagula-tion;
severe hypertriglyceridemic acute pancreatitis(HTG-AP)
- From:
The Journal of Practical Medicine
2025;41(4):561-568
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the efficacy of hemoperfusion(HP)in series with continuous renal replace-ment therapy(CRRT)integrated combined blood purification under extracorporeal citrate anticoagulation in the treatment of severe hypertriglyceridemic acute pancreatitis(HTG-AP).Methods A total of 62 patients with severe HTG-AP admitted to the Affiliated Hospital of Xuzhou Medical University from June 2022 to May 2024 were selected and randomly divided into control group and observation group,with 31 cases in each group.The control group was treated with conventional medical treatment+HP combined with CRRT staged combined blood purifica-tion treatment,and the observation group was treated with conventional medical treatment+HP in series with CRRT integrated combined blood purification treatment under extracorporeal citrate anticoagulation.The indexes and clinical efficacy before and 7 days after treatment were compared between the two groups.Results The single CRRT time of the observation group was longer than that of the control group,and the frequency of CRRT was less than that of the control group(P<0.05).There were no significant differences in the total CRRT time,single HP time,HP frequency and total HP time between the two groups(P>0.05).The blood routine,inflammatory factors,blood biochemistry and clinical scores of the two groups after treatment were improved compared with those before treatment(P<0.05).After treatment,the hemoglobin(Hb)and platelet count(Plt)of the observation group were higher than those of the control group(P<0.05),and there were no significant differences in other indexes of blood routine,inflammatory factors,blood biochemistry and clinical scores between the two groups(P>0.05).There were no significant differences in clinical indexes,prognosis and complications between the two groups(P>0.05).Conclusions Without affecting the efficacy,HP in series with CRRT integrated combined blood purification under extracorporeal citrate anticoagulation in the treatment of severe HTG-AP can prolong the use time of CRRT blood filter and pipeline,reduce the use of consumables,reduce the risk of bleeding,and avoid multiple catheter removal of HP and CRRT operation separately,and reduce the risk of related infection.It is worthy of clinical application.
