Biomaterials and bone regeneration:research hotspots and analysis of 500 influential papers
- VernacularTitle:生物材料与骨再生:研究热点及有影响力的500篇文献分析
- Author:
Kan JIANG
1
;
ALIMUJIANG·ABUDOUROUSULI
1
;
SHALAYIDING·AIERXIDING
1
;
AIKEBAIERJIANG·AISAITI
1
;
KUTILUKE·SHOUKEER
1
;
AIKEREMUJIANG·MUHEREMU
1
Author Information
- Publication Type:Journal Article
- Keywords: bone regeneration; biomaterial; bibliometrics; orthopedics; tissue engineering; visualization; CiteSpace; VOSviewer; engineered material
- From: Chinese Journal of Tissue Engineering Research 2026;30(2):528-536
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Novel biomaterials not only provide the necessary mechanical support but also promote cell proliferation and differentiation,inducing bone regeneration,thereby improving therapeutic outcomes and offering new perspectives and methods for the development of bone regenerative technologies.OBJECTIVE:To visualize the research status and development prospects of biomaterials in the field of bone regeneration through bibliometric methods.METHODS:A total of 500 of the most influential papers on bone regeneration and biomaterials were selected from the Web of Science Core Collection database from inception to September 24,2024.VOSviewer and CiteSpace tools were used for in-depth bibliometric visualization analysis to reveal the research trends and core literature in this field.RESULTS AND CONCLUSION:Among the selected 500 papers,China and the United States were in a leading position in terms of the number of published papers and citation rates,with ChangJiang being the most prolific author and the journal Acta Biomaterialia publishing the most articles.Bone regeneration and material science is an interdisciplinary research field,covering various disciplines including materials science,biomedical engineering,cell biology,and molecular biology.Research on bone repair materials is shifting from traditional bioinert materials to bioactive materials,which not only provide mechanical support but also promote cell proliferation and differentiation,inducing bone regeneration.Synthetic bone repair materials are gradually replacing traditional materials,becoming the preferred choice for clinical bone graft surgery due to their abundant sources,adjustable physicochemical properties,and lower risks of immune rejection and disease transmission.Researchers are continuously improving the biocompatibility,biomimetic properties,osteoconductivity,and osteoinductivity of these materials to make them closer to natural bone.The frontiers are mainly focused on bioactive ceramics,3D printing,hydrogels,chitosan,hydroxyapatite,and other materials.New materials play a vital role in the field of bone regeneration.With the continuous advancement of materials science and technology,the application prospects of these new materials in the field of bone regeneration are very broad,and they are expected to provide more effective and personalized treatment options for bone defect treatment.
