Application of chitosan in repair and regeneration of oral hard and soft tissues
- VernacularTitle:壳聚糖在口腔软硬组织修复与再生中的应用
- Author:
Zhuo WANG
1
;
Panpan SUN
1
;
Huanzhi CHENG
1
;
Tingting CAO
1
Author Information
- Publication Type:Journal Article
- Keywords: chitosan; pulp regeneration; remineralization; bone tissue engineering; drug-carrying antimicrobial; wound healing; engineered oral material
- From: Chinese Journal of Tissue Engineering Research 2026;30(2):459-468
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Chitosan has a place in the biomedical field due to its good biological properties and unique physicochemical properties,especially in tissue engineering and drug delivery with good application prospects.OBJECTIVE:To summarize the research progress of the role of chitosan in the repair and regeneration of oral soft and hard tissues.METHODS:A computerized search of CNKI and PubMed databases was performed with the search terms"chitosan,oral mucosal diseases,periodontal diseases,tissue regeneration,bacteriostatic,drug carrier,wound healing"in Chinese and English.The search time limit was from 2010 to 2024.After screening according to the inclusion and exclusion criteria,88 articles were finally included for summary analysis.RESULTS AND CONCLUSION:Chitosan is a promising biomaterial in bone and pulp regeneration as it has the ability to stimulate the recruitment and adhesion of osteogenic progenitor cells and dental pulp stem cells.Chitosan prevents caries,periodontal disease,and candidiasis by inhibiting Streptococcus pyogenes,Porphyromonas gingivalis,and Candida in the oral cavity.Chitosan nanocomposites have higher stability,better biocompatibility,and slow-release properties of drugs and can be enhanced by combining with other chemical reagents to enhance their anticancer properties.Chitosan possesses drug delivery,antibacterial activity,hemostasis and wound healing,which in turn can block the erosion of wounds by saliva and oral flora,relieve pain,repair and promote wound healing.Chitosan promotes the deposition of calcified material,which is conducive to the remineralisation of enamel and dentin.
