Effect of peripheral or intra-left atrium administration of unfractionated heparin on ACT value dur-ing left atrial appendage closure
10.3969/j.issn.1008-0074.2025.01.07
- VernacularTitle:经外周或左房肝素给药途径对左心耳封堵术中ACT监测的影响
- Author:
Cai-lan ZHANG
1
;
Xin ZHANG
1
Author Information
1. 上海交通大学医学院附属第九人民医院心内科,上海 200011
- Publication Type:Journal Article
- Keywords:
Atrial Fibrillation;
Left atrial appendage occlusion;
Heparin
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2025;34(1):32-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of different administration routes of unfractionated heparin(UFH)during left atrial appendage closure(LAAC)on activated clotting time(ACT)values and thrombosis event.Meth-ods:We retrospectively analyzed 96 patients with atrial fibrillation undergoing LAAC in Affiliated Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine between August 2020 and December 2021.According to administration routine of UFH,patients were divided into peripheral administration group(n=45)and left atrium administration group(n=51).Each group was given one-off 100 IU/kg UFH.ACT values at 20,40 and 60 min after first-dose UFH administration,incidence of perioperative thrombosis and bleeding were compared between two groups.Results:① There were no significant differences in baseline data,including age,gender,albumin,platelet count,hemoglobin,estimated glomerular filtration rate,preopcrative anticoagulant usages etc.between two groups(P＞0.05 all);② There were no significant difference in ACT values at 20,40 and 60min after adminis-tration between peripheral and left atrium administration(P＞0.05 all),but first-dose ACT standard-reaching rate in left atrium administration group was significantly higher than that of peripheral administration group(52.9％vs.31.1％,P=0.031);③ Left atrium administration group had lower incidence of perioperative thrombosis(2.0％vs.8.9％,P=0.287)comparing to peripheral administration group without statistical difference;there was no significant difference in incidence of perioperative bleeding between two groups(P=1.000).Conclusion:Intra-left atrium administration of unfractionated heparin could increase first-dose ACT standard-reaching rate(＞250s)and might provide a trend of decreased thrombosis.
