Changes of CK-MB and MYO levels and their correlation with heart rate deceleration capacity and heart rate variability in patients with acute myocardial infarction
10.3969/j.issn.1008-0074.2025.01.03
- VernacularTitle:急性心肌梗死患者CK-MB、MYO水平变化与心率减速力及心率变异性的相关性研究
- Author:
Rong LI
1
;
Li-fang LI
1
Author Information
1. 百色市人民医院心电诊断科,广西百色 533000
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Creatine kinase,MB form;
Myoglobin
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2025;34(1):12-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of levels of creatine kinase isoenzyme(CK-MB),myoglobin(MYO)with heart rate deceleration capacity(DC)and heart rate variability(HRV)in patients with acute myocar-dial infarction(AMI).Methods:A total of 117 AMI patients with complete clinical data admitted in People's Hospi-tal of Baise between July 2022 and June 2023 were included as the observation group,and 117 healthy subjects who received physical examination in our hospital simultaneously were selected as the control group.The CK-MB and MYO levels were compared between the two groups.Receiver operating characteristic curve(ROC)was used to an-alyze the diagnostic value of CK-MB,MYO and their combined detection for AMI.The DC and HRV were com-pared between the two groups.Pearson correlation analysis was used to analyze the association of CK-MB,MYO with DC and HRV indexes.Results:Compared with participants in control group,patients in observation group had significant higher CK-MB[(35.27±20.27)U/L vs.(18.06±3.65)U/L]and MYO[(233.88±13.83)μg/L vs.(30.87±5.08)μg/L](P＜0.001 all),and significant lower DC[(5.67±2.59)ms vs.(7.62±1.12)ms],heart rate deceleration run(DR)2[(8.07±0.69)％vs.(9.13±0.98)％],DR4[(0.41±0.10)％vs.(0.81±0.15)％],standard deviation of NN intervals(SDNN)[(80.24±27.82)ms vs.(142.45±16.79)ms],standard deviation of mean sinus R-R interval every 5 min(SDANN)[(67.25±24.47)ms vs.(115.12±12.18)ms],root mean square of successive differences(RMSSD)[(25.64±17.37)ms vs.(37.37±5.93)ms](P＜0.001 all).ROC analysis indicated that the area under the diagnostic curve(AUC)of combined detection(0.881)was signifi-cantly higher than those of single detection(Z=5.284,5.317,P＜0.001 all).Pearson correlation analysis showed that CK-MB was significantly negatively correlated with DC,DR2,DR4,SDNN,SDANN and RMSSD(r=-0.453～-0.639,P＜0.05 or＜0.01).There was a significant negative correlation between MYO and above-mentioned indexes(r=-0.438～-0.840,P＜0.05 or＜0.01).Conclusion:CK-MB and MYO have certain di-agnostic value for AMI,but the combined test has a higher diagnostic performance,and CK-MB and MYO are sig-nificantly negatively associated with both DC and HRV indicators.
