Predictive value of clinical data and CT signs for microvascular invasion in mass-forming type intrahepatic cholangiocarcinoma
10.3969/j.issn.1005-202X.2025.11.010
- VernacularTitle:临床及CT征象预测肿块型肝内胆管癌微小脉管浸润的价值
- Author:
Mingqiu LI
1
;
Xueqiao HUANG
1
;
Tingsong FANG
1
;
Jingyi ZHOU
1
Author Information
1. 佛山市中医院CT室,广东 佛山 528000
- Publication Type:Journal Article
- Keywords:
intrahepatic cholangiocarcinoma;
microvascular invasion;
computed tomography;
clinical data;
CT signs
- From:
Chinese Journal of Medical Physics
2025;42(11):1469-1472
- CountryChina
- Language:Chinese
-
Abstract:
Objective To preoperatively predict microvascular invasion(MVI)in intrahepatic cholangiocarcinoma(ICC)using clinical data and computed tomography(CT)signs.Methods A retrospective analysis was conducted on the preoperative clinical data and CT images of 173 ICC patients with complete surgical pathological results.Among them,102 were MVI-negative and 71 were MVI-positive.Results Statistically significant differences were observed between the MVI-positive and MVI-negative groups in liver cirrhosis,alpha-fetoprotein,alanine aminotransferase(ALT),margin,and capsule(P<0.05).Univariate analysis identified liver cirrhosis(OR=0.530,95%CI:0.286-0.983,P=0.044),unsmooth tumor margin(OR=19.362,95%CI:5.717-65.575,P<0.001),and incomplete capsule(OR=2.983,95%CI:1.544-5.760,P=0.001)as risk factors for predicting MVI.Multivariate analysis revealed that elevated ALT(OR=0.164,95%CI:0.030-0.884,P=0.035),unsmooth tumor margin(OR=35.816,95%CI:7.486-171.36,P<0.001),and incomplete capsule(OR=4.234,95%CI:1.211-14.801,P=0.024)were independent predictors of MVI.Conclusion Elevated ALT,unsmooth tumor margin,and incomplete capsule are highly correlated with MVI in ICC patients.
