Diagnostic value of shear wave elastography combined with carbohydrate antigen 15-3 for benign and malignant BI-RADS category 4 breast masses
10.3969/j.issn.1005-202X.2025.11.007
- VernacularTitle:超声剪切波弹性成像联合糖类抗原15-3诊断乳腺BI-RADS 4类肿块良恶性的价值
- Author:
Huali ZHANG
1
;
Yong WANG
;
Yuxue WANG
Author Information
1. 云南大学附属医院超声科,云南 昆明 650021
- Publication Type:Journal Article
- Keywords:
shear wave elastography;
carbohydrate antigen 15-3;
breast mass;
breast imaging and reporting data system;
differential diagnosis
- From:
Chinese Journal of Medical Physics
2025;42(11):1450-1454
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of shear wave elastography(SWE)combined with carbohydrate antigen 15-3(CA15-3)in differentiating benign and malignant breast imaging and reporting data system(BI-RADS)category 4 breast masses.Methods Ninety patients with breast tumors confirmed by surgical pathology at the Affiliated Hospital of Yunnan University from December 2021 to June 2024 were enrolled,all with BI-RADS category 4 breast masses.The patients were divided into a benign group(n=42)and a malignant group(n=48)according to whether the breast masses were benign or malignant.All of them underwent SWE examination,and serum CA15-3 levels were determined using electrochemiluminescence method.Serum CA15-3 levels and SWE parameters[elasticity standard deviation(ESD),mean elasticity value(Emean),maximum elasticity value(Emax)and the ratio of breast mass elasticity to same-layer low fat elasticity(Eratio)]were compared between the two groups.The area under the receiver operating characteristic curve(AUC)was used to evaluate the diagnostic performance of serum CA15-3 levels,SWE parameters,and their combination for benign and malignant BI-RADS category 4 breast masses.Results The SWE parameters(ESD,Emean,Emax,and Eratio)and serum CA15-3 levels in the malignant group were significantly higher than those in the benign group(P<0.05).The AUC values of ESD,Emean,Emax,Eratio,and serum CA15-3 levels for the diagnosis of benign and malignant BI-RADS category 4 breast masses were 0.718(95%CI:0.613-0.824),0.791(95%CI:0.701-0.881),0.721(95%CI:0.615-0.826),0.721(95%CI:0.613-0.830)and 0.793(95%CI:0.702-0.885),respectively.Notably,SWE parameters combined with serum CA15-3 levels achieved an AUC value of 0.953(95%CI:0.917-0.992).Conclusion The combination of CA15-3 and SWE exhibits high efficiency in diagnosing the benign and malignant nature of BI-RADS category 4 breast masses.
