Role of respiratory microbiota in the tumor immune microenvironment and immunotherapy of non-small cell lung cancer
10.12007/j.issn.0258-4646.2025.01.014
- VernacularTitle:呼吸道菌群在非小细胞肺癌肿瘤免疫微环境和免疫治疗中的作用
- Author:
Wenbo DONG
1
;
Haoyang YU
;
Yifan ZHU
;
Zhijian ZHANG
;
Wenyang LI
;
Delei KONG
Author Information
1. 中国医科大学第一临床学院109期,沈阳 110122
- Publication Type:Journal Article
- Keywords:
non-small cell lung cancer;
respiratory microbiota;
tumor immune microenvironment;
innate immunity;
adaptive immu-nity;
anti-tumor immunotherapy
- From:
Journal of China Medical University
2025;54(1):82-86
- CountryChina
- Language:Chinese
-
Abstract:
Microbiota can be recognized by the human immune system,trigger specific immune responses,and play a significant role in the onset and progression of diseases through intricate regulatory mechanisms.The tumor microenvironment comprises the peritumoral extracellular matrix,immune cells,tumor-associated fibroblasts,and endothelial cells,among others.In this context,the tumor immune microenvironment,characterized by immune cells,significantly influences cancer progression and treatment.Notably,the tumor immune microenvironment is closely associated with the tumor microbiota.The presence of respiratory microbiota is correlated with the typing and staging of non-small cell lung cancer.This study investigated the mechanisms by which respiratory microbiota affect innate and adaptive immune cells within the tumor immune microenvironment and explored the role of respiratory microbiota in the immunotherapy of non-small cell lung cancer.The aim was to identify potential biomarkers that could enhance the diagnosis and treatment of non-small cell lung cancer.
