Genetics Etiologies Associated with Fetal Growth Restriction
10.1097/FM9.0000000000000159
- VernacularTitle:Genetics Etiologies Associated with Fetal Growth Restriction
- Author:
Dayuan SHI
1
;
Luyao CAI
1
;
Luming SUN
1
Author Information
1. Shanghai Key Laboratory of Maternal Fetal Medicine, Department of Fetal Medicine & Prenatal Diagnosis Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 201204, China
- Publication Type:Journal Article
- Keywords:
Genetics;
Fetal growth restriction;
Etiology
- From:
Maternal-Fetal Medicine
2022;04(3):206-209
- CountryChina
- Language:English
-
Abstract:
Fetal growth restriction (FGR) is associated with multiple adverse perinatal outcomes, such as increased risk of intrauterine death, neonatal morbidity and mortality, and long-term adverse outcomes. Genetic etiological factors are critical in fetuses with intrauterine growth restriction, including chromosomal abnormalities, copy number variants, single gene disorders, uniparental disomy, epigenetic changes, and confined placental mosaicism. This paper aims to provide an overview of genetic defects related to FGR and to highlight the importance of prenatal genetic counseling and testing for precise diagnosis and management of FGR.
