The molecular basis of transcriptome molecules in forensic identification of challenging samples and their application in age estimation
10.13618/j.issn.1001-5728.2025.01.016
- VernacularTitle:转录组分子在法医疑难检材鉴定的分子基础及其在年龄推断中的应用
- Author:
Yanfang LU
1
;
Chengtao LI
Author Information
1. 复旦大学法庭科学研究院,上海 200032
- Publication Type:Journal Article
- Keywords:
Forensic genetics;
Transcriptome;
Challenging DNA samples;
Age estimation
- From:
Chinese Journal of Forensic Medicine
2025;40(1):90-95
- CountryChina
- Language:Chinese
-
Abstract:
Estimating an individual's age based on biological evidence found at a scene can provide valuable information for crime investigations and aid in identifying the identities of disaster victims.Developing novel age prediction methods remains a key focus in forensic medicine research.Traditional forensic age estimation,reliant on skeletal and dental morphological examinations,necessitates high sample integrity and is impractical for challenging samples.Currently,molecular methods for age estimation have begun to show effectiveness,especially the age inference method based on DNA methylation,which yields relatively accurate results.MicroRNAs and circRNAs in the transcriptome molecules,due to their short lengths and high stability,may hold greater potential for detecting challenging samples.This review provides an overview of the current state of predicting forensic age using transcriptome molecules,with particular emphasis on the research advancements involving microRNAs and circRNAs in age inference applications for challenging samples.
