Nucleic acid aptamer technology and its application in forensic analysis of mixed stain of sperm and vaginal epithelial cells
10.13618/j.issn.1001-5728.2025.01.015
- VernacularTitle:核酸适配体技术及其在法医学精阴混合斑中的应用
- Author:
Hao NIE
1
;
Jing CHEN
;
Xingchun ZHAO
;
Ruiqin YANG
Author Information
1. 中国人民公安大学侦查学院,北京 100038;公安部鉴定中心,北京 100038
- Publication Type:Journal Article
- Keywords:
Forensic evidence;
Mixed sample;
Aptamer;
Application prospect;
Evidentialization
- From:
Chinese Journal of Forensic Medicine
2025;40(1):83-89,95
- CountryChina
- Language:Chinese
-
Abstract:
The mixed samples of sperm and epithelial cells have long posed a technical challenge in forensic identification due to complex examination process,limited separation efficacy,and intricate result interpretation.To address this issue,it is beneficial to optimize the characterization of sperm cell-specific aptamer parameters using techniques such as molecular docking,high-throughput sequencing,and other molecular biology and chemical cross-fusion approaches.This will aid in enriching and separating single-source STR typing of sperm cells.This review examines,the development status,advantages and existing problems of aptamer technology,while exploring its potential application in forensic identification of spermatogenic mixed spot.The goal is to provide a new research idea for the detection and identification of mixed DNA samples,and also provide a basis for the evidentialization of the interpretation of mixed sample results,so as to promote the maximization of litigation benefits of scientific detection and identification results.
