The feasibility of bone mineral density screening using a proximal femur radiomics model derived from abdomen-pelvic CT scans
10.3969/j.issn.1002-1671.2025.02.030
- VernacularTitle:腹盆部CT股骨近端影像组学模型行骨密度筛查的可行性
- Author:
Changyu DU
1
;
Yijun LIU
1
;
Shigeng WANG
1
;
Xiaoyu TONG
1
;
Yong FAN
1
;
Wei WEI
1
;
Anliang CHEN
1
;
Jian HE
1
Author Information
1. 大连医科大学附属第一医院放射科,辽宁 大连 116011
- Publication Type:Journal Article
- Keywords:
osteoporosis;
radiomics;
opportunistic screening;
hip;
computed tomography
- From:
Journal of Practical Radiology
2025;41(2):310-314
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop an automated bone mineral density(BMD)assessment model based on proximal femur images from abdomen-pelvic CT scans and to analyze its application value in opportunistic osteoporosis(OP)screening.Methods A retrospective selection was conducted on 351 patients who underwent abdomen-pelvic plain CT examination.The patients were randomly divided into training set(n=245)and test set(n=106)in a ratio of 7∶3.All images were transferred to a quantitative computed tomography(QCT)post-processing workstation to measure the BMD of the left proximal femur.According to the QCT BMD T-score,the patients were divided into osteoporosis(T-score-2.5),osteopenia(-2.5＜T-score＜-1)and normal bone density(T-score≥-1).The left proximal femur was dissected using an automatic segmentation model,and two three-class BMD assessment radiomics models were constructed using random forest(RF)and logistic regression(LR)classifiers,respectively.The receiver operating characteristic(ROC)curves were generated,and the area under the curve(AUC),sensitivity,specificity and other metrics were calculated to evaluate the diagnostic performance of the two models.The DeLong test was used to compare differences between the models.Results In the test set,the AUC of the RF and LR models for identifying osteoporosis were 0.953 and 0.954,respectively.The AUC for identifying osteopenia were 0.894 and 0.870,and the AUC for identifying normal bone density were 0.975 and 0.982,respectively.The comparison of model performance showed no statistically significant differences between the RF and LR models in identifying the three bone states in both the training and test sets(P＞0.05).Conclusion Both the RF and LR radiomics models,constructed based on abdomen-pelvic plain CT scans,can be used for opportunistic BMD screening with high diagnostic efficiency.
