Meta-analysis on clinical characteristics of CMV infection in organ trans-plant recipients in China
10.12138/j.issn.1671-9638.20252281
- VernacularTitle:中国器官移植受者CMV感染临床特点的Meta分析
- Author:
Siyi ZHONG
1
;
Jingyi WU
;
Li ZHUANG
Author Information
1. 浙江树人学院树兰国际医学院附属树兰杭州医院肝胆胰外科,浙江 杭州 310022;浙江省人工器官与计算医学重点实验室,浙江 杭州 310022
- Publication Type:Journal Article
- Keywords:
cytomegalovirus;
solid organ transplant;
systematic review;
Meta-analysis;
China
- From:
Chinese Journal of Infection Control
2025;24(11):1608-1618
- CountryChina
- Language:Chinese
-
Abstract:
Objective To comprehensively describe the epidemiology,clinical outcomes,and treatment modes of post-transplant cytomegalovirus(CMV)infection in solid organ transplant(SOT)recipients in China.Methods Relevant studies were retrieved from domestic and foreign databases from 2013 to 2023.Indicators such as CMV in-fection incidence were included.Random-effects model analysis was conducted using R software.Results A total of 29 studies were included in the analysis,with an overall CMV infection incidence of 22.51％.CMV infection inci-dence after liver and kidney transplant were 23.62％and 13.01％,respectively.CMV infection rates after thoracic organ transplant were 52.27％and 61.24％.When serological status of donors and recipients was D+/R-,the in-cidence of CMV infection in transplant recipients was higher(83.89％).The incidence of CMV disease in CMV in-fected patients was 46.22％.Ganciclovir and valganciclovir were commonly used agents,but both had high risks of bone marrow suppression.Conclusion In China,CMV infection is a common viral infection after SOT surgery.Agents with better treatment efficacy and tolerance is necessary in clinics.
