Effect of macrophage polarization on osteogenesis-angiogenesis coupling in type 2 diabetic osteoporosis
10.12307/2026.530
- VernacularTitle:巨噬细胞极化对2型糖尿病性骨质疏松症成骨-成血管偶联的影响
- Author:
Wenqi CAO
1
;
Xiuzhi FENG
;
Yi ZHAO
;
Zhimin WANG
;
Yiran CHEN
;
Xiao YANG
;
Yanling REN
Author Information
1. 辽宁中医药大学,辽宁省沈阳市 110847
- Publication Type:Journal Article
- Keywords:
macrophages;
macrophage polarization;
type 2 diabetic osteoporosis;
osteogenesis-angiogenesis coupling;
M1 macrophages;
M2 macrophages;
immunomodulation
- From:
Chinese Journal of Tissue Engineering Research
2026;30(4):917-925
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Type 2 diabetes mellitus is a secondary causative factor for osteoporosis.As highly heterogeneous innate immune cells,macrophages may be polarized in a hyperglycemic environment,which affects osteogenesis-angiogenesis coupling.This may be a research target for improving bone quality in patients with type 2 diabetic osteoporosis.OBJECTIVE:To explore the role of modulating macrophage M1/M2 polarization to influence osteogenesis-angiogenesis coupling in type 2 diabetic osteoporosis and to summarize the effects of commonly used anti-glucose and anti-osteoporosis drugs and bone biorepair materials on bone osteogenesis-angiogenesis coupling by regulating macrophage M1/M2 polarization.METHODS:The keywords of"macrophage polarization,type 2 diabetes,osteoporosis,osteogenesis-angiogenesis coupling"in Chinese and"macrophages,macrophage polarization,osteogenesis-angiogenesis coupling"in English were used to search for relevant literature in CNKI and PubMed,respectively.Seventy-nine pieces of literature were screened and analyzed.RESULTS AND CONCLUSION:(1)Type 2 diabetes mellitus causes the body to be in a hyperglycemic environment and increases the secretion of inflammatory-related factors in the body,which promotes macrophage polarization towards M1 and decreases the number of M2 macrophages.(2)In type 2 diabetes,promoting M2 macrophage polarization is beneficial for osteogenesis-angiogenesis coupling.(3)Some anti-glycemic drugs,active ingredients in traditional Chinese medicine and bone biorepair materials can improve type 2 diabetic osteoporosis by regulating macrophage M1/M2 polarization,reducing M1/M2 ratio,and promoting osteogenesis-angiogenesis coupling.
