Involvement of macrophage polarization in osteoarticular diseases:a visual analysis based on SCI-Expanded information
- VernacularTitle:巨噬细胞极化参与骨关节疾病:来自SCI-Expanded信息的可视化分析
- Author:
Shunyi ZOU
1
;
Yuan CHAI
;
Kunjian LI
Author Information
- Publication Type:Journal Article
- Keywords: macrophage polarization; bibliometrics; visual analysis; Citespace; rheumatoid arthritis; osteoarticular disease; big data analysis
- From: Chinese Journal of Tissue Engineering Research 2025;29(24):5245-5253
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:In recent years,with the deepening of macrophage research,researchers have found that the pro-inflammatory and anti-inflammatory functions of macrophage polarization play a crucial role in the occurrence and progression of osteoarticular diseases.OBJECTIVE:To analyze the current status,hotspots,and development trends of macrophage polarization in osteoarticular diseases in order to provide reference for the subsequent scientific research work.METHODS:Using TS=("polarization of macrophages or macrophage polarization or macrophages polarization")AND TS=("arthritis or osteoarthritis or osteoporosis or degeneration intervertebral disc or necrosis of femoral head or rheumatoid arthritis")as the search formula,relevant literature addressing macrophage polarization in osteoarticular diseases were collected from the Web of Science Core Collection SCI-Expanded from January 01,2014 to June 01,2024.Citespace 6.3.R1 software was used for visual analysis of the publishing countries/regions,institutions,authors,journals,citation reference,and keywords,and then knowledge maps were drawn.RESULTS AND CONCLUSION:(1)A total of 420 papers were included after analysis and retrieval.The overall trend of publication volume is rising.The country with the highest volume and degree centrality is China.The institution with the most publications is Shanghai Jiao Tong University.The author with the most publications is Cai Daozhang.The journal with the most publications is International Immunopharmocology.(2)By integrating the frequency and centrality of keywords and excluding keywords directly related to the topic,it is known that the core keywords in this field are apoptosis,cartilage,differentiation,gene expression,and cytokines.(3)In the co-citation analysis of papers,among the top 10 cited documents,7 papers discuss the pathogenesis or therapeutic potential of macrophages in diseases,2 papers focus on the development of drugs or materials targeting macrophage polarization,and 1 paper reviews the current status of arthritis research.(4)Combining the co-citation analysis of papers and keywords,the current research hotspots focus on synergistic effect,the occurrence and regulatory mechanisms of polarization,the mechanism of transcriptomics,and the impact on related diseases and targeted tissues.As well,developing biomaterials with the function of regulating macrophage polarization and regulating the phenotype of macrophage polarization through drug targeting delivery systems may become the future research trends.
