Exploring the characteristics and clinical application of cerebral blood flow in children with congenital heart disease based on three-dimensional pseudo continuous arterial spin labeling technology
10.3969/j.issn.1002-1671.2025.02.023
- VernacularTitle:基于三维伪连续动脉自旋标记技术探究先天性心脏病患儿脑血流量特点及临床应用
- Author:
Peng LIU
1
;
Feng YANG
1
;
Ming YANG
1
Author Information
1. 南京医科大学附属儿童医院放射科,江苏 南京 210008
- Publication Type:Journal Article
- Keywords:
congenital heart disease;
magnetic resonance imaging;
arterial spin labeling;
region cerebral blood flow
- From:
Journal of Practical Radiology
2025;41(2):280-284
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the characteristics and clinical application of region cerebral blood flow(rCBF)in the gray matter,white matter,and deep gray matter nuclei of infants and young children with congenital heart disease(CHD)using MR three-dimensional pseudo continuous arterial spin labeling(3D-pCASL)technology.Methods The routine MRI and 3D-pCASL scanning images of 35 infants and young children with CHD aged 0-24 months were prospectively selected as the CHD group,and the images of 35 healthy infants and young children aged 0-24 months were selected as the control group,the differences in rCBF in gray matter,white matter,and deep gray matter nuclei between the two groups were compared,and the correlation between discipline quotient(DQ)scores in various functional areas of the Gesell developmental schedule(GDS)and rCBF in the CHD group were further analyzed.Results The rCBF in the gray matter,right caudate nucleus,bilateral thalamus,and left putamen of the CHD group was significantly lower than that of the control group;In the CHD group,the rCBF in the left putamen was significantly higher than that in the right putamen;Correlation analysis showed that the right caudate nucleus rCBF(r=0.669,P＜0.05),left caudate nucleus rCBF(r=0.584,P＜0.05),and left putamen rCBF(r=0.478,P＜0.05)in the CHD group were significantly positively correlated with adaptive DQ scores;The right caudate nucleus rCBF(r=0.659,P＜0.05)and left caudate nucleus rCBF(r=0.626,P＜0.05)were significantly positively correlated with fine motor DQ scores.Conclusion There are statistically significant differences in rCBF of the gray matter,right caudate nucleus,bilateral thalamus,and left putamen between the CHD group and the control group,and rCBF in multiple regions show significant positive correlation with GDS.3D-pCASL technology can provide cerebral blood characteristics in children with CHD and provide an important basis for clinical treatment.
