Characteristic analysis of nanogel composite system and its application strategies in visualization of diagnostic imaging and therapy
- VernacularTitle:纳米水凝胶复合系统特性分析及在可视化影像诊疗中的应用策略
- Author:
Qian ZHANG
1
;
Fuxia WANG
;
Wen WANG
;
Kun ZHANG
Author Information
- Publication Type:Journal Article
- Keywords: nanogel; visualization; imaging; integrated diagnosis and treatment; therapy; engineered material
- From: Chinese Journal of Tissue Engineering Research 2026;30(2):480-488
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Nanogels can combine the properties of nanoparticles and hydrogels,which have multiple advantages and can play a great role in clinical translation.OJECTIVE:To summarize the self-and cross-linking properties of nanogels,the diagnostic and therapeutic integration strategies they played in a variety of imaging processes,in conjunction with their functional visualization and application properties.METHODS:By searching PubMed,Web of Science,CNKI,and Wanfang databases,English and Chinese search terms were"nanogel,nanohydrogel,imaging,magnetic resonance imaging,fluorescence imaging,ultrasound imaging,photoacoustic imaging,multimodal imaging,therapy,treatment."According to the inclusion criteria,78 articles were finally selected for review.RESULTS AND CONCLUSION:The preparation process of nanogels is significantly affected by their multiple properties and cross-linking mechanisms.Optimization of these properties and mechanisms can help to improve their structural performance and accelerate the translation of their clinical applications.With the trend of integrated diagnosis and treatment,functional visualization of nanogels can effectively image tumors with the help of magnetic resonance imaging,fluorescence imaging,ultrasonography,photoacoustic imaging,and multimodal imaging,which can be of key value in the treatment strategies of various diseases.These findings not only pave the way for improving the preparation methods of nanogels,but also create a robust groundwork for hastening their clinical translation.
