Genetic Variants of Potassium Voltage-gated Channel Subfamily J Member 11 in Gestational Diabetes Mellitus: A Case-control Study
10.1097/FM9.0000000000000030
- VernacularTitle:Genetic Variants of Potassium Voltage-gated Channel Subfamily J Member 11 in Gestational Diabetes Mellitus: A Case-control Study
- Author:
Li-Jie WEI
1
;
Xuan ZHOU
1
;
Sheng-Lan ZHU
1
;
Jia-Qi LI
1
;
Yu ZENG
1
;
Jun YU
1
;
Shao-Shuai WANG
1
;
Ling FENG
1
Author Information
1. Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei 430030, China
- Publication Type:Journal Article
- Keywords:
Diabetes, gestational;
Polymorphism, single nucleotide;
Potassium channels, voltage-gated
- From:
Maternal-Fetal Medicine
2020;02(1):12-16
- CountryChina
- Language:English
-
Abstract:
Objective::To investigate the association of rs5210 in potassium voltage-gated channel subfamily J member 11 (KCNJ11) with gestational diabetes mellitus (GDM).Methods::Six hundred and thirty-two uncorrelated pregnancy females were recruited in Tongji hospital from October 2017 to June 2018, in which 241 pregnant women were identified as GDM, and 391 were non-GDM. All the pregnant women recruited in this study their peripheral venous blood of 5 mL were withdrawn, and DNA in the blood was extracted. rs5210 in KCNJ11 were genotyped using TaqMan Assays and genotype models were analyzed using logistic regression analyses.Results::After adjusting age and body mass index, the variant genotypes of rs5210 in genotype models were as follows: P for dominant model was 0.945, (odd ratio: 0.987, 95% confidence intervals ( CI): 0.681-1.430); P for recessive model: 0.556, (odd ratio: 1.217, 95% CI: 0.633-2.343) and P for addictive model was 0.098 (genotype AA vs. GG), (odds ratio: 1.435, 95% CI: 0.936-2.201). Weight-gain during pregnancy and total cholesterol were significantly different in recessive model ( P= 0.015, P= 0.022, respectively) of all participants. Conclusion::No significant association between gene susceptibility of rs5210 in KCNJ11 and GDM occurrence in Chinese pregnant women. But the variant of rs5210 was associated with weight-gain during pregnancy and total cholesterol blood levels. However, more cases are needed in genetic study to check its susceptibility with GDM occurrence in Chinese women.
