Application of multistimuli-responsive hydrogels in bone damage repair:special responsiveness and diverse functions
- VernacularTitle:多重刺激响应性水凝胶在骨损伤修复中的应用:特殊响应能力及多样性功能
- Author:
Yu WANG
1
;
Minjie FAN
1
;
Pengfei ZHENG
1
Author Information
- Publication Type:Journal Article
- Keywords: multistimuli-responsive hydrogel; smart hydrogel; bone damage repair; bone tissue engineering; engineered bone material
- From: Chinese Journal of Tissue Engineering Research 2026;30(2):469-479
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Multistimuli-responsive hydrogels have received extensive attention in the field of bone tissue engineering due to their special responsive capabilities and diverse functions.OBJECTIVE:To review the application of multistimuli-responsive hydrogels in bone damage repair,and explore their research and development ideas and future development directions.METHODS:Relevant literature was retrieved from PubMed,Web of Science,and WanFang databases.English search terms included"hydrogels,bone defect,bone repair,bone healing,bone tissue engineering,degenerative joint diseases,osteoarthritis,Cartilage."Chinese search terms were"multistimuli-responsive hydrogels,smart hydrogels,bone damage repair,bone tissue engineering."The search time limit was from database inception to August 2024.A total of 83 articles were included in the review.RESULTS AND CONCLUSION:Multistimuli-responsive hydrogels can react to various levels of physical,chemical,and biological stimuli,while exerting inherent functions such as swelling,deformation,degradation,and other special functions endowed by materials,making them highly potential in addressing clinical problems in bone damage repair.However,in practical applications,how to ensure that these materials maintain stability and durability in the complex biological environment and can be degraded in a controllable and harmless manner when needed is an urgent problem to be solved.
