Research Progress of Tumor-associated Macrophages in Esophageal and Gastrointestinal Malignancies
10.3969/j.issn.1008-7125.2024.08.007
- VernacularTitle:肿瘤相关巨噬细胞在食管和胃肠恶性肿瘤中的研究进展
- Author:
Chenyu YANG
1
;
Haoran XU
1
;
Qinglin ZHANG
1
;
Qiang ZHAN
1
Author Information
1. 南京医科大学附属无锡人民医院消化内科 南京医科大学无锡医学中心 国家消化系统疾病临床研究中心(西安)江苏省分中心(214023)
- Publication Type:Journal Article
- Keywords:
Esophageal Neoplasms;
Gastrointestinal Neoplasms;
Tumor-Associated Macrophages;
Therapy
- From:
Chinese Journal of Gastroenterology
2024;29(8):493-498
- CountryChina
- Language:Chinese
-
Abstract:
Esophageal and gastrointestinal malignancies have high morbidity and mortality.Their occurrence and development are complex processes involving numerous factors.Tumor-associated macrophages(TAM)are infiltrating macrophages in tumors,and play an important role in esophageal and gastrointestinal malignancies.This article focuses on the roles of TAM in esophageal and gastrointestinal malignancies,including promoting proliferation,invasion,migration and drug resistance of tumor cells,as well as the formation of immunosuppressive microenvironment.Meanwhile,we also summarized the application progress of TAM-targeting therapy in esophageal and gastrointestinal malignancies,such as reducing invasion,reprogramming tumor-associated macrophages,chimeric antigen receptor-macrophage(CAR-M)therapy and nanomaterials.In conclusion,the current studies of TAM in esophageal and gastrointestinal malignancies are still in a nascent stage,and more in-depth exploration of relevant mechanisms and more effective treatment methods are needed to give full play to harness the therapeutic potential of targeting TAM.
