Efficacy and Safety of Small Molecule Drugs in Treatment of Moderate-to-severe Ulcerative Colitis:A Meta-analysis
10.3969/j.issn.1008-7125.2024.08.003
- VernacularTitle:小分子药物治疗中重度溃疡性结肠炎疗效和安全性的meta分析
- Author:
Jianshu GAO
1
;
Jian LI
1
;
Longxiang ZHANG
1
;
Hongliang GAO
1
Author Information
1. 新疆医科大学第一附属医院消化病二科(830054)
- Publication Type:Journal Article
- Keywords:
Colitis,Ulcerative;
Small Molecule Drugs;
Meta-Analysis;
Therapy;
Safety
- From:
Chinese Journal of Gastroenterology
2024;29(8):459-469
- CountryChina
- Language:Chinese
-
Abstract:
Background:Ulcerative colitis(UC)is a chronic non-specific disease with potential for disability,and clinical treatment mainly relies on drugs.Currently,small molecule drugs(SMDs)have shown good application prospects.Aims:To evaluate the efficacy and safety of SMDs in the treatment of UC.Methods:Randomized controlled trials(RCTs)of SMDs in treatment of moderate-to-severe UC from CNKI,Wanfang Data,VIP,China Biomedical Literature Database,PubMed,Cochrane Library and Embase were searched from the establishment of the database to March 2024.References were screened and data extracted according to inclusion and exclusion criteria,and meta-analysis was performed using RevMan 5.3 software.Results:A total of 16 literatures involving 22 RCTs were finally included.Meta-analysis results suggested that SMDs had better efficacy indicators than placebo,such as clinical response rate(RR=1.86,95%CI:1.60-2.16,P<0.000 01),clinical remission rate(RR=3.01,95%CI:2.17-4.16,P<0.000 01),mucosal healing rate(RR=2.93,95%CI:2.27-3.79,P<0.000 01)and maintained response rate(RR=3.87,95%CI:3.11-4.81,P<0.000 01)were improved,and there was a statistical difference between them.And in terms of safety,SMDs compared to placebos,The incidence of adverse reactions(RR=1.02,95%CI:0.96-1.08,P=0.55),the incidence of serious adverse reactions(RR=0.77,95%CI:0.59-1.00,P=0.05),and the incidence of adverse reactions leading to drug withdrawal(RR=0.78,95%CI:0.59-1.02,P=0.07)were not statistically significant.Conclusions:SMDs are effective and safe in UC patients,which provides a new idea for the treatment of UC.
