Application progress of optogenetics in pathogenesis of epilepsy
10.3760/cma.j.cn371468-20250720-00340
- VernacularTitle:光遗传学技术在癫痫发病机制中的应用进展
- Author:
Ruting FU
1
;
Liya FANG
;
Jiahao LIU
;
Yuanyuan LIU
;
Yeyan WANG
;
Deming KONG
;
Jiawei LI
;
Jin GUO
Author Information
1. 佳木斯大学康复医学院，佳木斯 154007
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Optogenetics;
Pathogenesis;
Neural circuits;
Therapeutic targets
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2025;34(11):1051-1056
- CountryChina
- Language:Chinese
-
Abstract:
Epilepsy is a chronic brain disorder characterized by abnormal synchronous neuronal discharges in the brain, often accompanied by various complications. The pathogenesis of epilepsy has not yet been fully elucidated. Optogenetics, a cutting-edge technique that integrates optics and genetics, enables precise modulation of specific neurons by regulating light-sensitive proteins. Utilizing optogenetic technology has facilitated the dissection of neural circuits involved in epileptic seizures within brain regions such as the hippocampus, thalamus, hypothalamus. It has also helped identify potential therapeutic targets for epilepsy-related complications, including cognitive impairment, sudden unexpected death in epilepsy and mood disorders.However, in the process of advancing from basic research to clinical treatment, its translational path is profoundly influenced by factors such as stimulation modes (the choice between open-loop and closed-loop systems), key parameters (light frequency), and intervention strategies (unilateral or bilateral target selection). The individualized customization of these factors represents the future direction for overcoming current translational bottlenecks and achieving precise treatment.
