Changes in magnetic resonance imaging of anhedonia and psychosocial dysfunction in depression
10.3760/cma.j.cn371468-20241211-00594
- VernacularTitle:抑郁症快感缺失与心理社会功能损伤的脑影像学改变
- Author:
Mengjiao WU
1
;
Hui MA
1
;
Hao YANG
1
;
Wenyan HUANG
1
;
Ning ZHANG
1
Author Information
1. 南京医科大学附属脑科医院，南京 210029
- Publication Type:Journal Article
- Keywords:
Major depressive disorder;
Anhedonia;
Psychosocial function;
Magnetic resonance imaging;
Brain function;
Brain structure
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2025;34(7):658-663
- CountryChina
- Language:Chinese
-
Abstract:
Anhedonia is one of the core features of major depressive disorder (MDD) and is associated with poor functional outcomes in MDD patients. Psychosocial functional recovery is an important goal for achieving MDD remission. Although longitudinal studies have found association between anhedonia and impaired psychosocial function, there is still a lack of neurobiological biomarkers that can indicate this relationship. In this review, brain structural and functional changes associated with anhedonia and impaired psychosocial function in MDD patients are reviewed from the perspective of magnetic resonance imaging. It finds that anhedonia and psychosocial dysfunction in MDD may share common neuroimaging changes, manifested in abnormal brain regions such as the nucleus accumbens, caudate nucleus, putamen nucleus, orbitofrontal cortex, insula, amygdala, anterior cingulate cortex, dorsolateral prefrontal cortex, superior parietal lobe, inferior frontal gyrus and temporal lobe. These findings help to better understand the pathophysiology of the disease and offer potential insights for developing new treatment strategies.
