A Case of Severe Allergic Reaction Caused by Carboplatin
10.3870/j.issn.1004-0781.2025.02.023
- VernacularTitle:注射用卡铂致严重变态反应1例
- Author:
Shaolian SONG
1
;
Yuan LI
;
Chengyu LU
;
Xixiao YANG
;
Chunyan TANG
Author Information
1. 南方医科大学深圳医院药剂科,深圳 518000
- Publication Type:Journal Article
- Keywords:
Carboplatin;
Severe allergic reaction;
Adverse drug reaction
- From:
Herald of Medicine
2025;44(2):311-313
- CountryChina
- Language:Chinese
-
Abstract:
The patient was hospitalized for treatment due to ovarian cancer 22 months post-surgery and recurrence for 3 months.During chemotherapy,carboplatin was administered intravenously following pretreatment with dexamethasone and diphenhydramine to mitigate potential adverse reactions.Thirteen minutes after the administration of carboplatin,the patient developed an acute allergic reaction manifesting as chest tightness and skin itching,followed by a significant increase in heart rate and blood pressure,a decrease in blood oxygen saturation,laryngeal edema,and respiratory distress.In response to this emergency,the administration of carboplatin was immediately halted,fluid was extracted from the PICC line,and epinephrine,dexamethasone,and diphenhydramine were given for treatment.Additional supportive measures included oxygen therapy and fluid resuscitation.Following these interventions,the patient's condition stabilized,with blood oxygen saturation,heart rate and blood pressure returning to normal levels.
