Literature Analysis of Methimazole-induced Antineutrophil Cytoplasmic Antibody Associated Vasculitis
10.3870/j.issn.1004-0781.2025.02.020
- VernacularTitle:甲巯咪唑诱发中性粒细胞胞质抗体阳性相关性血管炎的文献分析
- Author:
Jinjin CAO
1
;
Ya LING
1
;
Xiufang CAO
1
;
Zhiwei ZHOU
1
;
Jie ZHANG
1
;
Rong CHEN
1
Author Information
1. 苏州大学附属第一医院药学部,苏州 215000
- Publication Type:Journal Article
- Keywords:
Methimazole;
Antineutrophil cytoplasmic antibody-associated vasculitis;
Adverse drug reaction
- From:
Herald of Medicine
2025;44(2):299-304
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the occurrence and characteristics of Antineutrophil cytoplasmic antibody(ANCA)associated vasculitis induced by methimazole,and to provide references for clinical safe drug use.Methods Case reports of ANCA associated vasculitis induced by methimazole published in Wanfang,CNKI,PubMed,and Web of Science were searched from the inception to October 31 st,2023.Demographic characteristics,drug use,complications,treatment and outcome were analyzed using descriptive statistical method.Results A total of 14 patients from 14literature were included.There were 3 males and 11 females with ages ranging from 8 to 79 years,with a mean age of(47.79±23.47)years.Four patients developed symptoms within 1 year,nine patients developed symptoms from 2 to 12 years,and 1 patient developed symptoms 24 years after medication.ANCA associated vasculitis affected kidney in 5 patients,lung and skin in 5patients,vision in 2 patients and heart in 2 patients.All patients discontinued methimazole,2 patients improved spontaneously without treatment,1 patient improved after anti-infection,and all others received hormonal or immunosuppressive therapy.1 patient developed death,and all others improved or were cured after treatment.Conclusions ANCA-associated vasculitis is a rare adverse reactionof methimazole.Most patients have a long latency period before the onset of disease,mainly involving multiple organs such asskin,kidney,lung,and eyesight.Clinicians should pay attention to differentiate it from primary vasculitis and discontinue the drug as soon as possible.When serious organ damage occurs,glucocorticoids and immunosuppressants should be adminstered promptly to avoid aggravation of the disease and endangerment of life.
