Blood Concentration Monitoring and Influencing Factors of Unbound Teicoplanin
10.3870/j.issn.1004-0781.2025.02.019
- VernacularTitle:游离替考拉宁血药浓度监测及其影响因素
- Author:
Jing WANG
1
;
Zejun WU
;
Lu JIN
;
Xuemei LUO
;
Huaijun ZHU
Author Information
1. 南京大学医学院附属鼓楼医院药学部,南京 210008;南京临床药学中心,南京 210008
- Publication Type:Journal Article
- Keywords:
Teicoplanin;
Therapeutic drug monitoring;
Unbound drug concentration
- From:
Herald of Medicine
2025;44(2):293-298
- CountryChina
- Language:Chinese
-
Abstract:
Teicoplanin,currently one of the preferred drugs for treating infections caused by multidrug-resistant Staphylococcus aureus and Enterococcus in clinical practice,has a high plasma protein binding rate.Most of the drug binds to protein after entering the body,only a portion of the drug exists in a free form.Since the free drug can pass through biological membranes and enter the target tissue to exert its therapeutic effect,monitoring the free teicoplanin blood concentration is clinically important and plays a role in guiding individualized drug therapy.This article summarizes and compares the current methods for determining the concentration of free teicoplanin in the blood,and analyzes their advantages and disadvantages.Based on this,it analyzes the possible factors affecting the concentration of free teicoplanin in the blood,providing a reference for the development of new methods for detecting free teicoplanin concentration and providing more accurate individualized medication plans based on free concentration.
