Advances of Baricitinib in the Pharmacological Effects and Clinical Application
10.3870/j.issn.1004-0781.2025.02.015
- VernacularTitle:巴瑞替尼药理作用与临床应用研究进展
- Author:
Chencheng WANG
1
;
Jinzhe ZENG
;
Xiaowei CHI
Author Information
1. 国家卫生健康委员会医药卫生科技发展研究中心,北京 100044
- Publication Type:Journal Article
- Keywords:
Baritinib;
JAK-STAT signaling pathway;
Inflammatory response;
Rheumatic autoimmune disease
- From:
Herald of Medicine
2025;44(2):267-272
- CountryChina
- Language:Chinese
-
Abstract:
Baricitinib is a new type and small molecule targeted disease-modifying antirheumatic drug.By targeting tyrosine protein kinase(JAK)1 and JAK2,it selectively inhibits the transcription,expression and response function of inflammatory cytokines,chemokines and cell growth factors that are involved in immune abnormalities regulated by the JAK-STAT pathway.A variety of pharmacological effects,such as anti-inflammatory,protecting musculoskeletal,reducing proteinuria and preventing inflammatory cytokine storm effects,and protecting skin and hair from immune damage,have shown good efficacy in a variety of rheumatic and autoimmune skin diseases.Based on the current basic and clinical research of baricitinib,this article gives an overview of the pharmacological effects and clinical application of baricitinib,and provides certain reference for the standardized and rational use of baricitinib in clinical practice.
