Regulatory mechanisms of exosome secretion and its application prospects in biomedicine
- VernacularTitle:外泌体分泌调控机制及在生物医学中的应用前景
- Author:
Ruyue LYU
1
;
Lulu GU
1
;
Qian LIU
1
;
Siyi ZHOU
1
;
Beibei LI
1
;
Letian XUE
1
;
Peng SUN
1
Author Information
- Publication Type:Journal Article
- Keywords: exosome; biological function; biogenesis; secretion or release; regulatory mechanism; engineered exosome
- From: Chinese Journal of Tissue Engineering Research 2026;30(1):184-193
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Exosomes,as a type of extracellular vesicle,have become a key medium for cell-to-cell communication due to their nanoscale size and enrichment of various bioactive substances.The study of exosome secretion regulation not only has important scientific value,but also has broad application prospects in clinical practice,and is of great significance for promoting medical progress and improving human health.OBJECTIVE:To review the biological characteristics,biological functions,biogenesis process and biochemical regulation mechanism of exosomes,and to explore the application prospects of exosomes in disease diagnosis,treatment and vaccine development,so as to provide theoretical basis and reference for basic research and clinical transformation of exosomes.METHODS:The first author searched PubMed and CNKI databases in October 2024 for relevant literature published from January 2010 to October 2024.Key words were"exosomes,biological functions,biogenesis,secretion or release,regulatory mechanisms,application prospects"in Chinese and English.Finally,92 articles were included for analysis.RESULTS AND CONCLUSION:The secretion level of exosomes can be regulated through physical or biochemical means.Exosomes show broad application prospects in the fields of disease diagnosis,treatment,and vaccine development,and may play a key role in the treatment of cardiovascular and cerebrovascular diseases as well as cancer.This review provides valuable information for the clinical translation and application research of exosomes,helping to promote future progress in exosome research and application.
